Gastric or Intestinal Hemorrhage - Rat

Prevention of gastric lesions induced by alcohol, aspirin, or NSAIDs in the rat performed in 24 hour fasted rats. Appropriate dose of test compound administered and followed 30-60 minutes later with lesion inducing agent. Rats sacrificed 3 hours later and stomach examined for presence of mucosal lesions. Prevention of perforating small intestine ulcers induced by indomethacin in the rat performed in fed rats. Test agent administered daily for three days. Indomethacin administered 1 hour after first dose of test agent. Rat sacrificed on third day. Rats receiving indomethacin alone will show significant incidence of small intestinal lesions.