Diet-Induced Obesity - C57BL/6J Mouse

The inbred mouse strain, C57BL/6J, is highly susceptible to development of obesity and diabetes upon feeding a high fat/high simple carbohydrate diet, whereas if left on normal chow, it will not develop metabolic syndrome. Obesity can be seen on the high fat/high simple carbohydrate diet after 10-12 weeks of treatment in which significant increases in body weight, adiposity and diabetes can be observed. Effects of anti-obesity (or anti-diabetic) drugs can be assessed by changes in body weight, body composition using DEXA as well as plasma glucose and insulin levels.