Subchronic Studies

PSL offers competitively priced subchronic toxicity studies that comply with international regulatory test guidelines, including the EPA, OECD and FDA 14-90 day toxicity protocols. Routes of administration include dietary, oral gavage and dermal (See Subchronic Prices). Full GLP analytical support, including dose concentration evaluation, method development and validation and stability are also available

Included when appropriate are:

  • Neurotoxicity assessments, including functional observation battery (FOB) and motor activity (MA),
  • Immunotoxicity,
  • The reproductive toxicity and developmental screens that are part of the OECD 421 and 422 protocols.

All studies are supervised by Dr Pam Marone, Director of Toxicology. Dr Marone had 20 years of experience in structural biology, drug delivery and development and pathology before joining PSL.

Protocols can be modified to make the studies more suitable for the clients needs. Pharmacology end-points can be added. PSL can also assist in manuscript review and preparation.