Subchronic/Chronic Studies

PSL offers competitively priced subchronic toxicity studies that comply with international regulatory test guidelines, including the EPA, OECD and FDA toxicity protocols. Routes of administration include dietary, oral gavage and dermal (See Repeat Dose Toxicology Prices) and IV. Full GLP analytical support, including dose concentration evaluation, method development and validation and stability are also available

Included when appropriate are:

  • Neurotoxicity assessments, including functional observation battery (FOB) and motor activity (MA),
  • Immunotoxicity,
  • The reproductive toxicity and developmental screens that are part of the OECD 421 and 422 protocols.
  • Carcinogenicity/Chronic Toxicity OECD 451-453

All studies are supervised by Dr Pam Marone, Director of Toxicology. Dr Marone had 20 years of experience in pathology, reproductive / developmental toxicology, structural biology and drug delivery and development before joining PSL.

Protocols can be modified to make the studies more suitable for the clients needs. Pharmacology end-points can be added. PSL can also assist in manuscript review and preparation.