Central Nervous System



Disease State or Symptom Animal Model or Test System
Behavioral Activity Irwin Screen - Rat, Mouse
Spontaneous motor activity - Mouse, Rat
Rotarod - Mouse, Rat
Anti-Convulsant Activity Metrazole - induced Seizures - Mouse
NMDA - induced seizures - Mouse, Rat
Pain - Visceral Acetylcholine / Acetic Acid-Induced Writhing - Mouse
Pain - Acute Hot Plate - Mouse
Tail Flick - Mouse
Hot Water -Tail Dip - Mouse
Pain - Inflammatory Carrageenan, Complete Freunl's Adjuvant - Rat
Post-Surgical Pain Plantar incision Rat
 
Neuropathic Pain Partial Sciatic Nerve Ligation (Seltzer) - Rat, Mouse
Spinal Nerve Ligation - Rat, Mouse
Chronic Constriction Injury (Bennett) - Rat, Mouse
Sedation Sleep Time - Mouse, Rat
Rotarod - Mouse, Rat
Nausea and Vomiting Induced Vomiting - Ferret
Parkinsonism Catalepsy - Mouse
Respiratory Depression Arterial blood gas - Rat, Mouse
Gastrointestinal Motility Gastrointestinal transit inhibition - Rat

 

Our behavioral pharmacologists are experienced in a variety of assays to screen experimental compounds against industry standards and evaluate their efficacy in the above models. Let us know your area of interest and we can develop a testing strategy that would suit your needs.