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Central Nervous System

Disease State or Symptom	Animal Model or Test System
Behavioral Activity	Irwin Screen - Rat, Mouse Spontaneous motor activity - Mouse, Rat Rotarod - Mouse, Rat
Anti-Convulsant Activity	Metrazole - induced Seizures - Mouse NMDA - induced seizures - Mouse, Rat
Pain - Visceral	Acetylcholine / Acetic Acid-Induced Writhing - Mouse
Pain - Acute	Hot Plate - Mouse Tail Flick - Mouse Hot Water -Tail Dip - Mouse
Pain - Inflammatory	Carrageenan, Complete Freunl's Adjuvant - Rat
Post-Surgical Pain	Plantar incision Rat
Neuropathic Pain	Partial Sciatic Nerve Ligation (Seltzer) - Rat, Mouse Spinal Nerve Ligation - Rat, Mouse Chronic Constriction Injury (Bennett) - Rat, Mouse
Sedation	Sleep Time - Mouse, Rat Rotarod - Mouse, Rat
Nausea and Vomiting	Induced Vomiting - Ferret
Parkinsonism	Catalepsy - Mouse
Respiratory Depression	Arterial blood gas - Rat, Mouse
Gastrointestinal Motility	Gastrointestinal transit inhibition - Rat

 

Our behavioral pharmacologists are experienced in a variety of assays to screen experimental compounds against industry standards and evaluate their efficacy in the above models. Let us know your area of interest and we can develop a testing strategy that would suit your needs.