PSL >> Pharmacology >> Central Nervous System

Central Nervous System

Disease State or Symptom

Animal Model or Test System

Behavioral Activity

Irwin Screen - Rat, Mouse
Spontaneous motor activity - Mouse, Rat
Rotarod - Mouse, Rat

Anti-Convulsant Activity

Metrazole - induced Seizures - Mouse

NMDA - induced seizures - Mouse, Rat

Pain - Visceral

Acetylcholine / Acetic Acid-Induced Writhing - Mouse

Pain - Acute

Hot Plate - Mouse
Tail Flick - Mouse
Hot Water -Tail Dip - Mouse
Paw Pressure - Mouse, Rat

Pain - Inflammatory

Carrageenan, Complete Freunds Adjuvant - Rat

Post-Surgical Pain

Plantar incision Rat

Neuropathic Pain

Partial Sciatic Nerve Ligation (Seltzer) - Rat, Mouse
Spinal Nerve Ligation - Rat, Mouse
Chronic Constriction Injury (Bennett) - Rat, Mouse


Sleep Time - Mouse, Rat
Rotarod - Mouse, Rat
Locomotor Activity - Mouse, Rat

Nausea and Vomiting

Induced Vomiting - Ferret


Catalepsy - Mouse

Respiratory Depression

Arterial blood gas - Rat, Mouse

Gastrointestinal Motility

Gastrointestinal transit inhibition - Rat

The behavioral pharmacologists at PSL are experienced in a variety of assays to screen experimental compounds to evaluate their efficacy and compare them to industry standard controls. Let us know your area of interest and we can develop a testing strategy that would suit your needs.